ARE FXR FAMILY PROTEINS INTEGRATORS OF DOPAMINE SIGNALING AND GLUTAMATERGIC NEUROTRANSMISSION IN MENTAL ILLNESSES?

Are FXR Family Proteins Integrators of Dopamine Signaling and Glutamatergic Neurotransmission in Mental Illnesses?

Dopamine receptors and related signaling pathways have long been implicated in pathophysiology and treatment of mental illnesses, including schizophrenia and bipolar disorder.Dopamine signaling may impact neuronal Cascara Sagrada activity by modulation of glutamate neurotransmission.Recent evidence indicates a direct and/or indirect involvement of

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Outliers vs Robustness in Nonparametric Methods of Regression

The article addresses the question of how robust methods of regression are against outliers in a given data set.In the first part, we presented the selected methods used to detect outliers.Then, we tested the robustness of three nonparametric methods Leather Breeks of regression: PPR, POLYMARS, and RANDOM FORESTS.The analysis was conducted applying

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